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Criteria

Primary ovarian insufficiency

The loss of ovarian activity before age 40 with disordered menstrual cycles and an elevated FSH level, diagnosed under the 2024 international guideline using one raised FSH.

Also called: POI, premature ovarian insufficiency

Criteria not met

2 amenorrhea fsh + 2 amenorrhea age

Disordered cycles with an elevated FSH
Before age 40 with pregnancy excluded

Educational use only. Guideline: ESHRE/ASRM/CREWHiRL/IMS guideline, 2024. Source: ESHRE, ASRM, CREWHiRL and IMS Guideline Group on POI. Evidence-based guideline: premature ovarian insufficiency. Human Reproduction Open. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11631070/; American Society for Reproductive Medicine. Current evaluation of amenorrhea: a committee opinion. 2024. https://www.asrm.org/practice-guidance/practice-committee-documents/current-evaluation-of-amenorrhea/; Yatsenko SA, Witchel SF, Gordon CM. Primary amenorrhea and premature ovarian insufficiency. Endocrinol Metab Clin North Am. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11110077/.

Learn it in

Card id: primary-ovarian-insufficiency

Sources

  • ESHRE, ASRM, CREWHiRL and IMS Guideline Group on POI. Evidence-based guideline: premature ovarian insufficiency. Human Reproduction Open. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11631070/
  • American Society for Reproductive Medicine. Current evaluation of amenorrhea: a committee opinion. 2024. https://www.asrm.org/practice-guidance/practice-committee-documents/current-evaluation-of-amenorrhea/
  • Yatsenko SA, Witchel SF, Gordon CM. Primary amenorrhea and premature ovarian insufficiency. Endocrinol Metab Clin North Am. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11110077/

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