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Congenital chloride diarrhea
A rare inherited intestinal disorder that causes lifelong chloride-rich secretory diarrhea.
Congenital chloride diarrhea results from altered intestinal chloride and bicarbonate transport associated with SLC26A3 mutations. It can begin before birth and continues as secretory diarrhea. A student may encounter it among congenital causes of persistent diarrhea, where chloride-rich stool helps distinguish its mechanism.