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FMR1

An X chromosome gene whose CGG repeat expansion past the premutation range causes fragile X syndrome while the premutation state damages ovarian follicles and causes POI.

gene whose premutation causes POI

Also called: FMR1 gene, Fragile X messenger ribonucleoprotein 1

Origin

Named for the fragile site on the X chromosome it occupies, where chromosomes visibly break

Card id: fmr1-gene-whose-premutation-causes-poi

Sources

  • Fragile X-associated primary ovarian insufficiency. MedlinePlus Genetics, National Library of Medicine, 2020. https://medlineplus.gov/genetics/condition/fragile-x-associated-primary-ovarian-insufficiency/
  • Hunter JE, Berry-Kravis E, Hipp H, Todd PK. FMR1 Disorders. GeneReviews, NCBI Bookshelf, 2024. https://www.ncbi.nlm.nih.gov/books/NBK1384/

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